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National Cholesterol Education Program, NationalHeart, Lung, and Blood Institute, National Institutes ofHealth. In such acase, where a reactive species produced during the metabo-lism of a chemical is responsible for its carcinogenicity, anappropriate cancer dose metric would be the lifetime averagedaily amount of metabolism in the target tissue divided bythe volume of the tissue, as was used in the PK riskassessment for methylene chloride

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Eplerenone, a selec-tive aldosterone blocker, in patients with left ventriculardysfunction after myocardial infarction.

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