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Long-term treatment is based on the concept that remainingbacteria cannot be killed by host defense, if the microorganisms persist as biofilm.Therefore, we suggest a 3-month course in case of debridement with implant retention,one-stage exchange, or two-stage exchange with a short interval (2–3 weeks) [30, 47, 48].For knee PJI, even a 6-month course is suggested [30, 47, 49].
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Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL (2001) HER2 (neu) signalingincreases the rate of hypoxia-inducible factor 1? (HIF-1?) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression.
pylori and resistance doesnot develop to it, combination regimens includingbismuth may be used in case of metronidazoleand clarithromycin double resistance. (2008).Maternal-fetal medicine: principles and practice (6th ed.) (2008).Maternal-fetal medicine: principles and practice (6th ed.).
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A signifi cant num-ber of cases may be asymptomatic, possibly refl ecting amilder form of disease or a presymptomatic state.